Cercosporamide是有效的Mnk1选择性抑制剂, 抑制eIF4E磷酸化, 具有抗白血病效应。HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 8
Cercosporamide是有效的Mnk1选择性抑制剂, 抑制eIF4E磷酸化, 具有抗白血病效应。HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 8