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Dock4 is a member of the dedicator of cytokinesis(DOCK) family and encodes a protein with a DHR-1(CZH-1) domain, a DHR-2(CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers.