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Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH(PubMed:2722838, PubMed:6894153). Involved in cellular response to oxidative stress(PubMed:25865492).