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收藏Basic Information
| Specificity | Species Reactivity | Clone | Conjugate and Tags | Tested Applications |
| Synuclein Alpha , SNCA, α-synuclein | Human | L46 | Un-conjugated; with HA, LPETG and8*His tags at its C-terminal | IHC |
| Purification | Product Buffer Solution | Format | Analyte Description | |
| Affinity chromatography purified via Ni-charged resin | 25 mM TAPS pH8.5, 500 mM NaCl, 5 mM EDTA, 0.1 % Proclin 300 Solution | Liquid | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body. |
Parameters on Each Lot
| Product Concentration | Purity | Recommended Dilutions | ||
| 0.626 mg/mL by Nanodrop | ≥95% (4-12% gradient SDS-PAGE) | IHC 1:50-1:250 |
Datasheet for JOT0134.pdf