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Integrin alpha V (4Z14) Rabbit Monoclonal Antibody
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原料试剂 研发实验室
价格
¥2250.00
品牌 EnkiLife/恩玑
地区 中国,湖北省,武汉市
货号 AMRe12656
产地 国产
选择规格
100μL
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EnkiLife
武汉EnkiLife-log科技有限公司
武汉
营业执照已审核
武汉恩玑生命科技有限公司(EnkiLife)是一家聚焦细胞生物学和免疫学的生物技术企业,致力于为生命科学行业的科研工作者提供高质量的产品和卓越的客户服务。 EnkiLife的产品线包括细胞系、原代细胞、培养基、血清、细胞检测试剂盒、蛋白、抗体、ELISA试剂盒、生化试剂盒等,并提供技术服务与定制开发,全方位满足生命科学行业需求,为您的实验保驾护航! EnkiLife的技术团队凭借在生物科学领域的丰富经验和专业知识,已在公司内部构建了一套完善的技术平台,涵盖细胞培养及检测、蛋白表达、抗体制备以及免疫学等多个关键领域。我们始终秉承严格的质量管理体系,优化生产流程,确保为客户提供高效、精准的技术支持。 展望未来,EnkiLife将继续致力于技术创新,不断丰富和完善我们的技术平台,以更好地满足客户需求,同时不断提升服务水平,确保客户体验的持续优化。我们期待与更多的全球科研工作者携手合作,共同推动生命科学领域的进步与发展。
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产品规格 图文详情 技术文档
产品规格
品牌名称
EnkiLife/恩玑
货号
AMRe12656
国产/进口
国产
规格
100μL
图文详情

产品概述

产品名称(Product Name)

Integrin alpha V (4Z14) Rabbit Monoclonal Antibody

描述(Description)

Rabbit Monoclonal Antibody

宿主(Host)

Rabbit

应用(Application)

WB

种属反应性(Reactivity)

Human,Mouse,Rat

 

产品性能

偶联物(Conjugation)

Unconjugated

修饰(Modification)

Unmodified

同种型(Isotype)

IgG

克隆(Clonality)

Monoclonal

形式(Form)

Liquid

存放说明(Storage)

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

储存溶液(Buffer)

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

纯化方式(Purification)

Affinity purification

 

免疫原

免疫原信息(Immunogen Information)

0

基因名(Gene Name)

ITGAV

别名(Alternative Names)

CD51; Integrin alpha five; integrin alpha V beta 3; Integrin alpha-V light chain; ITGAV; Msk8;Vitronectin receptor subunit alpha; VNRA; VTNR;

基因ID(Gene ID)

3685

蛋白ID(SwissProt ID)

P06756

 

产品应用

稀释比(Dilution Ratio)

WB: 1:2000

蛋白分子量(Molecular Weight)

116kDa

 

研究背景

The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1- dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha- V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF- beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973).

 

研究领域

技术文档
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