EnkiLife/恩玑HRPT2 / CDC73 (19W5) Rabbit Monoclonal AntibodyAMRe12208EnkiLife,恩玑-易享

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HRPT2 / CDC73 (19W5) Rabbit Monoclonal Antibody

原料试剂研发实验室

价格

￥2250.00

品牌 EnkiLife/恩玑

地区中国,湖北省,武汉市

货号 AMRe12208

产地国产

选择规格

100μL

易享客服

EnkiLife

武汉EnkiLife-log科技有限公司

武汉

营业执照已审核

武汉恩玑生命科技有限公司（EnkiLife）是一家聚焦细胞生物学和免疫学的生物技术企业，致力于为生命科学行业的科研工作者提供高质量的产品和卓越的客户服务。 EnkiLife的产品线包括细胞系、原代细胞、培养基、血清、细胞检测试剂盒、蛋白、抗体、ELISA试剂盒、生化试剂盒等，并提供技术服务与定制开发，全方位满足生命科学行业需求，为您的实验保驾护航！ EnkiLife的技术团队凭借在生物科学领域的丰富经验和专业知识，已在公司内部构建了一套完善的技术平台，涵盖细胞培养及检测、蛋白表达、抗体制备以及免疫学等多个关键领域。我们始终秉承严格的质量管理体系，优化生产流程，确保为客户提供高效、精准的技术支持。展望未来，EnkiLife将继续致力于技术创新，不断丰富和完善我们的技术平台，以更好地满足客户需求，同时不断提升服务水平，确保客户体验的持续优化。我们期待与更多的全球科研工作者携手合作，共同推动生命科学领域的进步与发展。

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产品规格图文详情技术文档

产品规格

品牌名称

EnkiLife/恩玑

货号

AMRe12208

国产/进口

国产

规格

100μL

图文详情

产品概述

产品名称（Product Name）	HRPT2 / CDC73 (19W5) Rabbit Monoclonal Antibody
描述（Description）	Rabbit Monoclonal Antibody
宿主（Host）	Rabbit
应用（Application）	WB,ELISA
种属反应性（Reactivity）	Human,Mouse,Rat

产品性能

偶联物（Conjugation）	Unconjugated
修饰（Modification）	Unmodified
同种型（Isotype）	IgG
克隆（Clonality）	Monoclonal
形式（Form）	Liquid
存放说明（Storage）	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
储存溶液（Buffer）	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
纯化方式（Purification）	Affinity purification

免疫原

免疫原信息（Immunogen Information）	0
基因名（Gene Name）	CDC73
别名（Alternative Names）	Cdc73; FIHP; HPTJT; HRPT1; HRPT2; Hyperparathyroidism 2; HYX;
基因ID（Gene ID）	79577
蛋白ID（SwissProt ID）	Q6P1J9

产品应用

稀释比（Dilution Ratio）	WB 1:500-1:2000
蛋白分子量（Molecular Weight）	61kDa

研究背景

Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors.

研究领域

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