产品概述
| 产品名称(Product Name) | PINCH (3C12) Mouse Monoclonal Antibody |
| 描述(Description) | Primary antibody |
| 宿主(Host) | Mouse |
| 应用(Application) | WB,ICC/IF,FC,IP |
| 种属反应性(Reactivity) | Human |
产品性能
| 偶联物(Conjugation) | Unconjugated |
| 修饰(Modification) | Unmodified |
| 同种型(Isotype) | IgG1 |
| 克隆(Clonality) | Monoclonal Antibody |
| 形式(Form) | Liquid |
| 存放说明(Storage) | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 储存溶液(Buffer) | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| 纯化方式(Purification) | Ascitic Fluid |
免疫原
| 基因名(Gene Name) | LIMS1 |
| 别名(Alternative Names) | LIMS1; PINCH; PINCH1; LIM and senescent cell antigen-like-containing domain protein 1; Particularly interesting new Cys-His protein 1; PINCH-1; Renal carcinoma antigen NY-REN-48 |
| 基因ID(Gene ID) | 3987 |
| 蛋白ID(SwissProt ID) | P48059 |
产品应用
| 稀释比(Dilution Ratio) | WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20 FC: 1/50-1/100 |
| 蛋白分子量(Molecular Weight) | Calculated MW: 37 kDa; Observed MW: 37 kDa |
研究背景
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
研究领域
Cardiovascular