产品概述
| 产品名称(Product Name) | CRK (3H7) Mouse Monoclonal Antibody |
| 描述(Description) | Primary antibody |
| 宿主(Host) | Mouse |
| 应用(Application) | WB |
| 种属反应性(Reactivity) | Human |
产品性能
| 偶联物(Conjugation) | Unconjugated |
| 修饰(Modification) | Unmodified |
| 同种型(Isotype) | IgG2b |
| 克隆(Clonality) | Monoclonal Antibody |
| 形式(Form) | Liquid |
| 存放说明(Storage) | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 储存溶液(Buffer) | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| 纯化方式(Purification) | Affinity Purified |
免疫原
| 基因名(Gene Name) | CRK |
| 别名(Alternative Names) | Adapter molecule crk; avian sarcoma virus CT10 (v-crk) oncogene homolog; CRK; CRKII; Proto-oncogene c-Crk |
| 基因ID(Gene ID) | 1398 |
| 蛋白ID(SwissProt ID) | P46108 |
产品应用
| 稀释比(Dilution Ratio) | WB: 1/500-1/1000 |
| 蛋白分子量(Molecular Weight) | Calculated MW: 34 kDa; Observed MW: 34 kDa |
研究背景
The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
研究领域
Neuroscience