产品概述
| 产品名称(Product Name) | ATM (9F7) Mouse Monoclonal Antibody |
| 描述(Description) | Primary antibody |
| 宿主(Host) | Mouse |
| 应用(Application) | IHC |
| 种属反应性(Reactivity) | Human,Rat,Mouse |
产品性能
| 偶联物(Conjugation) | Unconjugated |
| 修饰(Modification) | Unmodified |
| 同种型(Isotype) | IgG1 |
| 克隆(Clonality) | Monoclonal Antibody |
| 形式(Form) | Liquid |
| 存放说明(Storage) | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 储存溶液(Buffer) | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| 纯化方式(Purification) | Affinity Purified |
免疫原
| 基因名(Gene Name) | ATM |
| 别名(Alternative Names) | ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated |
| 基因ID(Gene ID) | 472 |
| 蛋白ID(SwissProt ID) | Q13315 |
产品应用
| 稀释比(Dilution Ratio) | IHC: 1/50-1/100 |
| 蛋白分子量(Molecular Weight) | - |
研究背景
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.
研究领域
Epigenetics and Nuclear Signaling