| 产品名称 | GMP Recombinant Human TGF-β3 |
| 蛋白名 | TGF-β3 |
| 纯度 | Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 | ≤10 EU/mg |
| 蛋白构建 | Recombinant Human TGF-β3 is produced by our Mammalian cell expression system and the target gene encoding Ala 301-Ser 412 is expressed. |
| Accession # | P10600 |
| 蛋白标签 | Tag free |
| 表达宿主 | Mammalian cell |
| 种属 | Human |
| 预测分子量 | 13 kDa |
| 蛋白形态 | Lyophilized |
| 储存缓冲液 | 100 mM Glycine, 150 mM NaCl, 5% mannitol and 0.01% Tween 80, pH 4.0 |
| 运输方式 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
分子别名
Transforming growth factor beta-3; TGFB3; TGF-beta-3; Latency-associated peptide; LAP
蛋白活性
The ED50 for this effect is ≤0.2ng/mL.
背景介绍
Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3,mammals develop a deformity known as a cleft palate.
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