| 产品名称 | GMP Recombinant Human IL-23 |
| 蛋白名 | IL-23 |
| 纯度 | Greater than 95% as determined by reducing SDS-PAGE |
| 内毒素 | ≤10 EU/mg |
| 蛋白构建 | Recombinant Human IL-23 is produced by our Mammalian cell expression system and the target gene encoding Ile23-Ser328&Arg23-Pro189 is expressed. |
| Accession # | P29460(P40), AAG37232(P19) |
| 蛋白标签 | Tag free |
| 表达宿主 | Mammalian cell |
| 种属 | Human |
| 预测分子量 | 55.0 kDa(IL-23singlechain);36.5 kDa(p40)&18.5 kDa(p19) |
| 蛋白形态 | Lyophilized |
| 储存缓冲液 | PBS,5% mannitol and 0.01% Tween 80, pH7.4 |
| 运输方式 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
| 稳定性&储存 | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
| 复溶 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
分子别名
SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2
蛋白活性

The ED50 for this effect is <0.5 μg/mL.
背景介绍
Interleukin-23 (IL-23) is a heterodimeric cytokine that belongs to the IL-12 cytokine family. It is composed of two subunits, p19 and p40, with the p40 subunit being shared with IL-12. IL-23 is primarily secreted by activated macrophages and dendritic cells located in peripheral tissues such as skin, intestinal mucosa, and lung. This cytokine plays a crucial role in the development and maintenance of autoimmune inflammation, particularly through its ability to induce IL-17 production, which is a unique role compared to IL-12.