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SARS-CoV-2-IN-19 is a potent inhibitor of SARS-CoV-2 (EC50: 8.8 μM). SARS-CoV-2-IN-19 is effective against SARS-CoV-2 decapping enzyme (nsp13), a highly conserved enzyme that exhibits potential against emerging HCoV outbreaks. SARS-CoV-2-IN-19 exhibits research potential for infectious diseases.