图文详情
HIV-1 protease-IN-6 (compound 17d) is a potent inhibitor of HIV-1 protease (IC50: 21 pM, Ki: 4.7 pM). HIV-1 protease-IN-6 showed significant antiviral activity against DRV (darunavir) resistant mutants, even exceeding the intensity of inhibition against wild-type viruses.