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Cap-dependent endonuclease-IN-10 is a potent inhibitor of cap-dependent nucleic acid endonucleases (CEN). cap-dependent endonuclease-IN-10 effectively inhibits influenza viruses with low cytotoxicity, good in vivo pharmacokinetic and in vivo pharmacodynamic properties, and good hepatic microsomal stability. Cap-dependent endonuclease-IN-10 has shown investigational potential against viral infections, including influenza A, B and C.