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Antifungal agent 22 (compound D16) is an orally active, potentially antifungal agent (IC50: 0.5 μg/mL) with blood-brain barrier permeability, good metabolic stability and low cytotoxicity. Antifungal agent 22 is a selective anti-cryptococcal agent that kills C. neoformansH99 cells by disrupting the integrity of the fungal cell membrane.