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Cathepsin C-IN-5 (compound SF38) is a potent, selective, and orally active inhibitor of Cathepsin C, demonstrating IC50 values of 59.9 nM for Cat C, and showing significantly lower potency against Cat L (4.26 µM), Cat S, Cat B, and Cat K (all >5 µM). It effectively reduces Cat C activity in bone marrow and blood, diminishes the activation of NSPs (neutrophil serine proteases), and exhibits anti-inflammatory activity [1].