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Narsoplimab (OMS 721) is a selective whole-human immunoglobulin gamma-4 (IgG4) monoclonal antibody, a mannan-binding lectin-associated serine protease-2 (MASP-2) inhibitor that binds MASP-2 and prevents lectin pathway activation. It can inhibit the agglutinin pathway. Narsoplimab can be used to study diseases associated with hematopoietic stem cell transplantation in adults.