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Antioxidant agent-8 is an orally active compound that inhibits the deposition of Aβ 1-42 by preventing fibril aggregation (IC 50 =11.15 µM) and aiding in fibril disaggregation (IC 50 =6.87 µM). Moreover, it effectively counters Cu2+-induced Aβ 1-42 fibril aggregation and disaggregation, exhibiting lower IC 50 values of 3.69 µM and 3.35 µM, respectively. This compound also possesses antioxidant and anti-inflammatory activities, demonstrates biosafety and blood-brain barrier permeability, and offers a neuroprotective effect.