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16-Hydroxycleroda-3,13-dien-15,16-olide and prodigiosin are candidates for autophagy inducers that can trigger cell death as a supplement or alternative medicine for cancer therapy. 16-Hydroxycleroda-3,13-dien-15,16-olide regulates the expression of histone-modifying enzymes (PRC2 complex) and induces apoptosis in CML [K562] cells; it also exhibits anti-inflammatory activity, showing promising NO inhibitory activity at 10 ug/mL.