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SMARCA4, Human, 重组蛋白 (His)
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产品可用于生物细胞实验
原料试剂 研发实验室
价格
¥1470.00-7700.00
品牌 TargetMol
地区 中国
货号 TMPH-02217
产地 进口
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20 μg
100 μg
500 μg
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TargetMol (陶术生物)
上海陶术生物科技有限公司
上海
营业执照已审核
上海陶术生物科技有限公司深耕药物发现领域十余年,始终聚焦生物医药行业配套产品和服务,利用自身技术优势,提供小分子药物大数据信息、海量实体化合物供应、科研服务等新药发现的整体解决方案。为全球各类创新药物的研发带来便捷、高效的产品和服务,助力降低研发投入、提高研发效率。陶术生物先后荣获国家“高新技术”企业、上海“专精特新”企业、国家“专精特新”小巨人企业等称号。 陶术生物主营品牌 TargetMol Chemicals Inc.,总部位于美国马萨诸塞州波士顿,作为一家全球性的生物医药领域高科技企业,TargetMol可向全球科学家提供种类丰富的高质量产品和服务,包括抑制剂和激动剂、化合物库、天然产物、重组蛋白、多肽、抗体、试剂盒以及300多种技术服务等。TargetMol于2023年荣获由全球生命科学领域权威平台CiteAb颁发的“最值得关注的生化试剂供应商”奖项,合作伙伴遍布全球。TargetMol可提供 20,000+ 种 抑制剂和激动剂 、 800+ 种 化合物库 、19,000+ 种 天然产物 ,以及 9,000+ 种 重组蛋白 、多种 多肽 、抗体 和 生命科学试剂盒 等。此外,在上海,TargetMol研发中心配备了 CADD & AIDD 研究中心、药理实验室和药物化学合成 平台三大技术中心,可提供虚拟筛选、化合物活性测试、分子间结合力检测和化合物结构优化等技术服务,多方位满足用户的研发需求。已被近 4000 篇文献所引用,包括 《Nature》、《Science》和 《Cell》 等国际顶级期刊,随着产品引用量的增加,TargetMol于2023年荣获由全球生命科学领域权威平台CiteAb颁发的“最值得关注的生化试剂供应商”奖项。
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产品规格 图文详情 技术文档
产品规格
品牌名称
TargetMol
货号
TMPH-02217
国产/进口
进口
规格
20 μg,100 μg,500 μg
图文详情
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2. Binds to RNA in a promiscuous manner. Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities.
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