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TRIM21, Mouse, 重组蛋白 (E. coli, His)
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产品可用于生物细胞实验
原料试剂 研发实验室
价格
¥1800.00-14600.00
品牌 TargetMol
地区 中国
货号 TMPH-02632
产地 进口
选择规格
100 μg
20 μg
1 mg
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TargetMol (陶术生物)
上海陶术生物科技有限公司
上海
营业执照已审核
上海陶术生物科技有限公司深耕药物发现领域十余年,始终聚焦生物医药行业配套产品和服务,利用自身技术优势,提供小分子药物大数据信息、海量实体化合物供应、科研服务等新药发现的整体解决方案。为全球各类创新药物的研发带来便捷、高效的产品和服务,助力降低研发投入、提高研发效率。陶术生物先后荣获国家“高新技术”企业、上海“专精特新”企业、国家“专精特新”小巨人企业等称号。 陶术生物主营品牌 TargetMol Chemicals Inc.,总部位于美国马萨诸塞州波士顿,作为一家全球性的生物医药领域高科技企业,TargetMol可向全球科学家提供种类丰富的高质量产品和服务,包括抑制剂和激动剂、化合物库、天然产物、重组蛋白、多肽、抗体、试剂盒以及300多种技术服务等。TargetMol于2023年荣获由全球生命科学领域权威平台CiteAb颁发的“最值得关注的生化试剂供应商”奖项,合作伙伴遍布全球。TargetMol可提供 20,000+ 种 抑制剂和激动剂 、 800+ 种 化合物库 、19,000+ 种 天然产物 ,以及 9,000+ 种 重组蛋白 、多种 多肽 、抗体 和 生命科学试剂盒 等。此外,在上海,TargetMol研发中心配备了 CADD & AIDD 研究中心、药理实验室和药物化学合成 平台三大技术中心,可提供虚拟筛选、化合物活性测试、分子间结合力检测和化合物结构优化等技术服务,多方位满足用户的研发需求。已被近 4000 篇文献所引用,包括 《Nature》、《Science》和 《Cell》 等国际顶级期刊,随着产品引用量的增加,TargetMol于2023年荣获由全球生命科学领域权威平台CiteAb颁发的“最值得关注的生化试剂供应商”奖项。
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产品规格 图文详情 技术文档
产品规格
品牌名称
TargetMol
货号
TMPH-02632
国产/进口
进口
规格
100 μg,20 μg,1 mg
图文详情
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses. Represses the innate antiviral response by facilitating the formation of the NMI-IFI35 complex through 'Lys-63'-linked ubiquitination of NMI.
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