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AGI-41998 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A) that penetrates the blood-brain barrier.AGI-41998 inhibits s-adenosylmethionine (SAM) metabolizing enzymes and methionine adenosyltransferase 2A (MAT2A) for the treatment of cancer and for studying the role of SAM regulation in the central nervous system (CNS).