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Mecbotamab vedotin (BA3011) is a humanized IgG1-κ antibody engineered to target the AXL receptor tyrosine kinase (AXL). Serving as a conditionally active biologic (CAB), mecbotamab is conjugated to monomethyl auristatin E (MMAE) through a cleavable linker, creating an antibody-drug conjugate (ADC) for therapeutic use [1] [2].