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VISTA-IN-2 (Compound 1) is a V-domain Ig suppressor of T-cell activation (VISTA) inhibitor that promotes the degradation of VISTA in cells via autophagy, reverses VISTA-related immunosuppression, and fortifies the antitumor responses of immune cells. Additionally, this compound stimulates antitumor immunity and suppresses tumor growth in a CT26 mouse model [1].