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Dicyclomine (Dicycloverine) is a potent and orally active antagonist of muscarinic cholinergic receptors. Dicyclomine is an antispasmodic agent which relieves smooth muscle spasm of the gastrointestinal tract in vivo. Dicyclomine has high affinity for muscarinic M1 receptor subtype and M2 receptor subtype with Ki values of 5.1 nM and 54.6 nM in brush-border membrane and basal plasma membranes, respectively [1] [2].