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SB 258585 is a selective 5-HT6 receptor antagonist.SB 258585 has a high affinity for individual receptor populations in cell lines with human recombinant 5-HT6 receptors.SB 258585 can be used to label both recombinant and natural 5-HT6 receptors, and can be used to assay cognitive enhancement and antipsychotic activity.