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Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values of 9.5 and 10.6, respectively.Vofopitant dihydrochloride is a potential compound for the treatment of pathological vomiting. Vofopitant dihydrochloride is a potential compound for the treatment of pathological vomiting.