Musk protein (Muscle-specific Kinase, MUSK) is a tyrosine kinase specifically expressed in muscle tissue, primarily involved in the development and maintenance of neuromuscular junctions. MUSK plays a key role in synapse formation by promoting the formation and stability of synapses through its interaction with nerve growth factors released by neurons. MUSK plays an important role in the development of neuromuscular junctions by interacting with proteins on the neuronal membrane, facilitating the clustering of receptors on the muscle cell membrane. MUSK activates various signaling pathways, regulating the functions and growth of muscle cells. MUSK also plays a crucial role in the differentiation and growth of muscle cells, influencing the muscle development process. Abnormalities in MUSK may be associated with certain diseases, such as myasthenia syndrome, making research on MUSK helpful for understanding related physiological and pathological mechanisms. Scientists are exploring the potential of MUSK as a therapeutic target, particularly in the treatment of neuromuscular diseases.