产品描述

The product CSB-E04586h is a sandwich ELISA kit developed to measure concentrations of human IGFBP1 in serum, plasma, or tissue homogenates. This assay uses the sandwich enzyme immunoassay technique in combination with the enzyme-substrate chromogenic reaction to quantify the analyte in the sample. The color develops positively to the amount of IGFBP1 in samples. The color intensity is measured at 450 nm via a microplate reader.

IGFBP1 is produced dominantly in the liver, heart, and kidney. It binds to insulin-like growth factor (IGF) and regulates IGF actions in somatic growth, development, and aging. IGFBP-1 not only is an important determinant of IGF activity but also enhances glucose uptake in peripheral tissues and decreases glucose output in the liver. It regulates cell proliferation, migration, and glucose metabolism by activating integrin-ILK/FAK/PTEN signaling through integrin receptors on the cell membrane. Low circulating levels of IGFBP1 are related to insulin resistance and predict the development of type 2 diabetes. Dysregulation of IGFBP1, as well as IGFs in serum and cervical secretions, induces metabolic disease and cardiovascular disease. Overexpression of IGFBP1 has been shown to improve impaired glucose tolerance.

别名

AFBP ELISA Kit; Alpha pregnancy associated endometrial globulin ELISA Kit; Amniotic fluid binding protein ELISA Kit; Binding protein 25 ELISA Kit; Binding protein 26 ELISA Kit; Binding protein 28 ELISA Kit; Growth hormone independent binding protein ELISA Kit; hIGFBP 1 ELISA Kit; hIGFBP1 ELISA Kit; IBP 1 ELISA Kit; IBP-1 ELISA Kit; IBP1 ELISA Kit; IBP1_HUMAN ELISA Kit; IGF binding protein 1 ELISA Kit; IGF BP25 ELISA Kit; IGF-binding protein 1 ELISA Kit; IGFBP 1 ELISA Kit; IGFBP-1 ELISA Kit; IGFBP1 ELISA Kit; Insulin like growth factor binding protein 1 ELISA Kit; Insulin-like growth factor-binding protein 1 ELISA Kit; Placental protein 12 ELISA Kit; PP 12 ELISA Kit; PP12 ELISA Kit

缩写

IGFBP1

Uniprot No

P08833

灵敏度

0.39 ng/mL

反应时间

1-5h

样本体积

50-100ul

检测波长

450 nm

研究领域

Signal Transduction

测定原理

quantitative

货期

3-5 working days