产品描述

The product CSB-EL011616HU is a sandwich ELISA kit developed to measure levels of human interleukin-36 receptor antagonist protein (IL-36Ra) in serum, plasma, or tissue homogenates. The enzyme-substrate chromogenic reaction is also used to amplify the signal and quantify the levels of the analyte through the intensity of the colored product. The color intensity positively correlates with the amount of IL1F5 bound in the initial step.

IL-36Ra, also called IL1F5, functions as a receptor antagonist that inhibits the activation of IL-36R signaling. It induces inflammatory responses by activating NF-κB and MAPKs via an intracellular signaling cascade. In contrast, IL-36Ra suppresses pro-inflammatory signaling by binding to and inhibiting IL-36R activation. It is highly expressed in the skin, brain, tonsils, spleen, and various immune cell types such as macrophages, monocytes, B cells, and dendritic cells (DCs). Loss-of-function homozygous or compound heterozygous mutations in its encoding gene IL36RN have been implicated in the pathogenesis of various skin disorders.

别名

AI413231 ELISA Kit; Family of interleukin 1 delta ELISA Kit; FIL1 ELISA Kit; FIL1 delta ELISA Kit; FIL1(DELTA) ELISA Kit; FIL1D ELISA Kit; Fil1delta ELISA Kit; I36RA_HUMAN ELISA Kit; IL 1 delta ELISA Kit; IL 1 related protein 3 ELISA Kit; IL 1F5 (IL 1HY1, FIL1 delta, IL 1RP3, IL 1L1, IL 1 delta) ELISA Kit; Il 1h3 ELISA Kit; IL 1HY1 ELISA Kit; IL 1L1 ELISA Kit; IL 1ra homolog ELISA Kit; IL 1ra homolog, IL1F5 (Canonical product IL 1F5a) ELISA Kit; IL 1RP3 ELISA Kit; IL-1 delta ELISA Kit; IL-1-related protein 3 ELISA Kit; IL-1F5 ELISA Kit; IL-1HY1 ELISA Kit; IL-1L1 ELISA Kit; IL-1ra homolog 1 ELISA Kit; IL-1RP3 ELISA Kit; IL1F5 ELISA Kit; IL1HY1 ELISA Kit; IL1L1 ELISA Kit; IL1RP3 ELISA Kit; IL36RA ELISA Kit; IL36RN ELISA Kit; Interleukin 1 delta ELISA Kit; Interleukin 1 family member 5 (delta) ELISA Kit; Interleukin 1 family member 5 ELISA Kit; Interleukin 1 HY1 ELISA Kit; Interleukin 1 like protein 1 ELISA Kit; Interleukin 1 receptor antagonist homolog 1 ELISA Kit; Interleukin 36 receptor antagonist ELISA Kit; Interleukin-1 delta ELISA Kit; Interleukin-1 family member 5 ELISA Kit; Interleukin-1 HY1 ELISA Kit; Interleukin-1 receptor antagonist homolog 1 ELISA Kit; Interleukin-1-like protein 1 ELISA Kit; Interleukin-36 receptor antagonist protein ELISA Kit; MGC29840 ELISA Kit; PSORP ELISA Kit; RP23-176J12.6 ELISA Kit

缩写

IL1F5

Uniprot No

Q9UBH0

灵敏度

7.8 pg/ml

反应时间

1-5h

样本体积

50-100ul

检测波长

450 nm

研究领域

Immunology

测定原理

quantitative

货期

3-5 working days