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收藏The human follistatin like protein 1 (FSTL1) ELISA kit is suitable for the quantitative determination of human FSTL1 in serum, plasma, or tissue homogenates. This assay employs the bi-antibody sandwich technique and enzyme-substrate chromogenic reaction to quantify human FSTL1 levels in the sample. The amount of synthesized colored products is positively related to the analyte of interest in the sample.
FSTL1 is expressed in nearly all cell types and concentrated in normal placenta, smooth muscle with diverse roles in different biological processes, particularly in cell proliferation and migration. FSTL1 plays an indispensable during embryogenesis. It is also involved in heart injury, lung development and fibrosis, arthritis, and woung healing. Upregulation of FSTL1 facilitates keratinocyte migration during wound healing, as well as angiogenesis and survival through AKT signaling in the infarcted hearts. FSTL1 can modulate cell cycle entry to improve cardiac function and cardio-renal communication. In the kidney, FSTL1 is expressed in the loop of Henle and prevents the kidney from being attacked by acute nephrotoxic injury.