产品描述

The product CSB-E17377h is a sandwich ELISA kit developed to measure concentrations of human CCL7 in serum, plasma, or tissue homogenates. This assay uses the sandwich enzyme immunoassay technique in combination with the enzyme-substrate chromogenic reaction to quantify the analyte in the sample. The color develops positively to the amount of CCL7 in samples. The color intensity is measured at 450 nm via a microplate reader.

CCL7 is a potent chemoattractant for various leukocytes, including monocytes, eosinophils, basophils, dendritic cells (DCs), NK cells, and activated T lymphocytes. As a chemotactic factor, CCL7 recruits a leukocyte subtype to infected tissues to address pathologic invasion and fine-tune the immune response by binding to its receptors including CCR1, CCR2, CCR3, CCR5, and CCR10. CCL7 plays an important role in various pathologies, including cancers, auto-immune diseases, and chronic inflammation. It promotes tumor progression by supporting the formation of the tumor microenvironment and facilitating tumor invasion and metastasis.

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