产品描述

This Human anti-cyclic citrullinated peptide antibody (anti-CCP antibody, ACCPA) ELISA Kit is designed to qualitatively detect the anti-CCP antibody in the serum. It employs the qualitative enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with CCP antigen. Samples are pipetted into the wells with anti-human IgG conjugated HRP. Any antibodies specific for CCP present in the samples will bind to the pre-coated CCP antigen. Following a wash to remove any unbound reagent, the TMB substrate solution is added to the wells and color develops in proportion to the amount of human anti-CCP antibody bound in the initial step. The color development is stopped and the intensity of the color is measured by a microplate reader at 450 nm.

This assay has high sensitivity and excellent specificity for detection of human anti-CCP antibody. And it also has been validated with precision less than 15% and lot-to-lot consistency. Get more details from the product instructions.

ACCPA is a type of autoantibodies against citrullinated peptides and proteins. They target healthy tissues in the joints. And they are detected in the majority of patients suffering from rheumatoid arthritis (RA). An ACCPA test is helpful for the diagnosis of RA, along with or after a rheumatoid factor (RF) test. ACCPA is predictive of the progression of patients, indicating more erosive disease or increase joint involvement.

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