产品描述

The product CSB-E04662h is a sandwich ELISA kit developed to measure concentrations of human macrophage inflammatory protein-1α (MIP-1α) in serum, plasma, or tissue homogenates. This assay uses the sandwich enzyme immunoassay technique in combination with the enzyme-substrate chromogenic reaction to quantify the analyte in the sample. The color develops positively to the amount of MIP-1α in samples. The color intensity is measured at 450 nm via a microplate reader.

MIP-1α, also called CCL3, is a pro-inflammatory chemokine expressed constitutively in the bone marrow, including by osteoblasts. It is induced during inflammation. CCL3 is a chemotactic cytokine crucial for inflammatory cell recruitment in homeostatic and pathological conditions. In addition to its proinflammatory activities, CCL3 negatively regulates the proliferation of hematopoietic stem/progenitor cells (HSPCs) in the bone marrow (BM). CCL3 and its receptor CCR1 are reported to mediate the bone remodeling that occurs during orthodontic tooth movement, and may also regulate osteoclastogenesis in osteomyelitis. CCL3 might stimulate cancer progression by promoting leukocyte accumulation, angiogenesis, and tumor growth.

别名

C C motif chemokine 3 ELISA Kit; CCL 3 ELISA Kit; CCL3 ELISA Kit; CCL3_HUMAN ELISA Kit; Chemokine (C C motif) ligand 3 ELISA Kit; Chemokine C C motif ligand 3 ELISA Kit; Chemokine ligand 3 ELISA Kit; G0/G1 switch regulatory protein 19 1 ELISA Kit; G0/G1 switch regulatory protein 19-1 ELISA Kit; G0S19 1 ELISA Kit; G0S19 1 protein ELISA Kit; Heparin binding chemotaxis protein ELISA Kit; L2G25B ELISA Kit; LD78 alpha ELISA Kit; LD78-alpha(4-69) ELISA Kit; LD78alpha ELISA Kit; Macrophage inflammatory protein 1 alpha ELISA Kit; Macrophage inflammatory protein 1-alpha ELISA Kit; macrophage inflammatory protein 1a ELISA Kit; MIP 1 alpha ELISA Kit; MIP 1A ELISA Kit; MIP-1-alpha ELISA Kit; MIP-1-alpha(4-69) ELISA Kit; MIP1 alpha ELISA Kit; MIP1A ELISA Kit; PAT 464.1 ELISA Kit; SCYA 3 ELISA Kit; SCYA3 ELISA Kit; SIS alpha ELISA Kit; SIS beta ELISA Kit; SIS-beta ELISA Kit; Small inducible cytokine A3 ELISA Kit; small inducible cytokine A3 (homologous to mouse Mip-1a) ELISA Kit; Small-inducible cytokine A3 ELISA Kit; Tonsillar lymphocyte LD78 alpha protein ELISA Kit

缩写

CCL3

Uniprot No

P10147

灵敏度

9.75 pg/ml

反应时间

1-5h

样本体积

50-100ul

检测波长

450 nm

研究领域

Immunology

测定原理

quantitative

货期

3-5 working days