索莱宝SolarbioK009451P Anti-P53(wt-p53) Polyclonal AntibodyK009451Psolarbio,索莱宝-易享

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K009451P Anti-P53(wt-p53) Polyclonal Antibody

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Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by control

原料试剂研发实验室

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品牌索莱宝Solarbio

地区中国,北京,北京市

货号 K009451P

产地国产

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50ul

100ul

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北京索莱宝科技有限公司

北京市通州区中关村科技园区通州园金桥科技产业基地景盛南四街15号85A三层

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北京索莱宝科技有限公司（Beijing Solarbio Science & Technology Co.,Ltd.）是一家从事生物学试剂及试剂盒的高科技生物企业。总部位于北京，并在全国设有经销或代理机构。产品因可靠而稳定的质量和完善的售后服务确立了“Solarbio”良好的品牌形象。公司秉承“以客户为中心、以产品为保障、以诚信为基础、以创新为宗旨”的发展理念，拥有专业的研发和质量检测团队以及先进的仓储和物流系统。“Solarbio”已经得到全国科研工作者的认可，成为广大经销商推崇的知名品牌。

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产品规格图文详情技术文档

产品规格

品牌名称

索莱宝Solarbio

货号

K009451P

国产/进口

国产

规格

50ul,100ul

图文详情

Anti-P53(wt-p53) Polyclonal Antibody - 产品详情 (solarbio.com)

英文名称	Anti-P53(wt-p53) Polyclonal Antibody
中文名称	肿瘤蛋白P53抗体
宿主	Rabbit
克隆类型	Polyclonal Antibody
亚型	IgG
交叉反应	Rat ; Mouse ; Human
预测交叉反应	Pig;Cow;Horse;Rabbit;Sheep
应用	ELISA ; FCM ; IF ; ICC ; IHC ; WB
稀释比例	WB 1:500-2000. ELISA 1:5000-10000. IHC 1:100-500. FCM 1μg/Test . ICC 1:100. IF 1:100-500.
靶标	P53(wt-p53)
别名	Widespread p53;Wtp53;Antigen NY-CO-13;Cellular tumor antigen p53;Cys 51 Stop;HGNC11998;LFS1;p53;p53 Cellular Tumor Antigen;p53 Tumor Suppressor;Phosphoprotein p53;TP53;Transformation related protein 53;TRP53;Tumor protein p53;Tumour Protein p53;P53_HUMAN;TP53.
背景说明	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Swiss Prot	P04637
Gene ID	7157
亚细胞定位	Cytoplasm Endoplasmic reticulum Mitochondrion matrix Nucleus PML body
免疫原	A synthetic peptide of human P53(wt-p53)
Public Immunogen Range	251-310/393aa
理论分子量	23/30/34/38/44kDa
纯化方法	Affinity purification
储存液	Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
储存条件	Store at -20℃. Avoid freeze / thaw cycles.
规格	50ul ; 100ul
单位	支

以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。

These protocols are for reference only. Solarbio does not independently validate these methods.

使用前请离心。如有问题请及时联系我们。

Quick spin before use. If you have any questions, please contact us.

实验图

Western blot analysis with P53 protein(wt-p53) antibody diluted at 1:300;Lane: HepG2 Mcf-7 DU145.

Immunohistochemistry of paraffin-embedded human breast cancer with P53(wt-p53) antibody diluted at 1:400

Immunofluorescence analysis of A549 cells using P53(wt-p53) antibody diluted at 1:100.

Immunohistochemistry of paraffin-embedded mouse esophageal with P53 antibody diluted at 1:200.

Immunofluorescence analysis of A549 cell using P53 antibody diluted at 1:100.

实验图

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