Streptozocin是一种有效的 DNA甲基化 试剂。STZ可使鼠类的血糖升高，是一种常用的糖尿病造模诱导剂，同时STZ的糖尿病作用具有种属差异性。本产品不稳定，建议现配现用。使用本产品的应用案例（仅供参考）In VivoRats（male Sprague?Dawley rats，250?300 g，10 weeks old；65 mg/kg Streptozocin；腹腔注射）A total of 20 male Sprague?Dawley rats (250?300 g, 10 weeks old) were fasted for 12 h and intraperitoneally injected with streptozotocin (65 mg/kg) to induce type I diabetes mellitus. Rats with blood glucose level above 16.7 mmol/L under normal conditions were regarded as successful diabetic animal models and were utilized for surgery.来源文献：Hao Z, Liu G, Ren L, Liu J, Liu C, Yang T, Wu X, Zhang X, Yang L, Xia J, Li W. A Self-Healing Multifunctional Hydrogel System Accelerates Diabetic Wound Healing through Orchestrating Immunoinflammatory Microenvironment. ACS Appl Mater Interfaces. 2023 Apr 26;15(16):19847-19862. doi: 10.1021/acsami.2c23323. Epub 2023 Apr 12. PMID: 37042619.Rats（Wistar rats；25 mg/kg Streptozotocin；i. p.）In some experiments, high fat diet - streptozotocin (HFD-STZ) diabetic rat were used. To this end, 4-week-old Wistar rats were fed on a 60% high fat diet (HFD) for 8 weeks and then received 25 mg/kg i. p. streptozotocin (Solarbio, China). Their blood was sampled at 13 weeks of age.来源文献：Zhen D, Ding L, Wang B, Wang X, Hou Y, Ding W, Portha B, Liu J. Oral administration of kynurenic acid delays the onset of type 2 diabetes in Goto-Kakizaki rats. Heliyon. 2023 Jun 27;9(7):e17733. doi: 10.1016/j.heliyon.2023.e17733. PMID: 37424591; PMCID: PMC10328841.Mice （Male ICR mice (6-week old, 30±2 g) ，35mg/kg STZ，腹腔注射， 1次/周，共4次）After one week of acclimation, mice were fed with a 60% high-fat diet for hyperglycemic model induction. After 9 weeks, the HFD-fed mice were intraperitoneally injected with STZ (35 mg/kg) once a week for 4 times. One week later, the fasting blood glucose level (FBG) was measured after 12 h fasting, and the mice with FBG > 8 mM were considered as hyperglycemic model mice. Subsequently, the model group was divided into control and Up-U groups. The Up-U group was orally administered with Up-U at a dose of 200 mg/kg/day for 12 weeks. The control group was orally administered with the same amount of sterile water and all hyperglycemic model mice were fed with a 60% high-fat diet. The mice fed with a chow diet during the whole experiment were used as the blank group. The FBG levels of the mice were measured after 12 h fasting for every 4 weeks.来源文献：Zhong QW, Zhou TS, Qiu WH, Wang YK, Xu QL, Ke SZ, Wang SJ, Jin WH, Chen JW, Zhang HW, Wei B, Wang H. Characterization and hypoglycemic effects of sulfated polysaccharides derived from brown seaweed Undaria pinnatifida. Food Chem. 2021 Mar 30;341(Pt 1):128148. doi: 10.1016/j.foodchem.2020.128148. Epub 2020 Sep 22. PMID: 33038776.Mice（Male C57BL/6 J mice；55 mg/kg Streptozotocin, 腹腔注射, 3d）Male C57BL/6 J mice (Eight- to ten-week-old) were kept under specific pathogen-free conditions. After a fast of 12 h, mice received intraperitoneal injection of 55 mg/kg/d streptozotocin (Solarbio, Beijing, China) or equal volume of citrate buffer (0.1 M, pH = 4.5) respectively for 3 d. Mice with a fasting plasma glucose level > 16 mmol/L were chosen to use in this study. Mice were randomly divided into 3 groups: sham group, MCAO/R group and MCAO/ R + Dex group. Mice in the MCAO/R + Dex group were injected in_x005f traperitoneally with Dex (25 μg/kg) after MCAO/R surgery.来源文献：Chen L, Cao J, Cao D, Wang M, Xiang H, Yang Y, Ying T, Cong H. Protective effect of dexmedetomidine against diabetic hyperglycemia-exacerbated cerebral ischemia/reperfusion injury: An in vivo and in vitro study. Life Sci. 2019 Oct 15;235:116553. doi: 10.1016/j.lfs.2019.116553. Epub 2019 Jun 8. PMID: 31185237.