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COL6A6 belongs to the type VI collagen family and is an extracellular matrix component highly expressed in the lungs, adipose tissue, and skeletal muscle. It provides structural support and regulates signaling by inhibiting the PI3K-Akt pathway to play a tumor-suppressive role. Its abnormalities are closely linked to skin inflammation, retinitis pigmentosa, and pituitary adenoma, making it a potential diagnostic marker or therapeutic target.