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Sortilin is a multifunctional type-I transmembrane protein belonging to the Vps10p-domain receptor family (Vps10p-Domain Receptors, Vps10p-DRs). Sortilin plays a central role in cellular protein sorting, signal transduction, and metabolism. Its dysfunction is closely related to neurodegenerative diseases, metabolic syndrome, and cancer, and it is a potential therapeutic target for diseases.