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SARS‑CoV‑2 NB.1.8.1 is an Omicron‑descendant variant under monitoring, first detected in early 2025. It carries multiple spike mutations linked to immune escape and shows a growth advantage over co‑circulating BA.2.86/JN.1 lineages2. While currently at low prevalence in many regions, it is spreading in parts of Asia and is expected to rise, though no major increase in disease severity is anticipated.