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ADAM28 is a member of the ADAM (A Disintegrin And Metalloprotease) family, which are transmembrane or secreted proteins with diverse functions, including shedding of cell surface proteins, cell adhesion, and proteolysis of extracellular matrix components. ADAM28 possesses both disintegrin and metalloprotease domains, allowing it to mediate cell-cell or cell-matrix interactions and cleave various substrates.