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Cluster Differentiation 90 (CD90) is a cell adhesion molecule and the smallest member of the immunoglobulin superfamily with a molecular weight of 25–35 KDa. CD90 is also known as thymocyte differentiation antigen-1 (Thy-1) based on its presence on mouse thymocytes. CD90 is a glycoprotein anchored to the cell surface via a glycosylphosphatidylinositol (GPI) motif . Expression of CD90 differs among species. In humans, CD90 is expressed on stem cells including Mesenchymal Stem Cells (MSCs), Hematopoietic Stem Cells (HSCs) and Keratinocytic Stem Cells (KSCs) and at varying levels on non-lymphoid tissues such as fibroblasts, neurons and activated endothelial cells.