Description:NebuSelect™ Recombinant Human ALK-1/Activin RL1, His-tag(Cat#NBL-243117) is expressed in HEK293 with His tag at the C-Terminus.It contains Asp22-Gln118.

Species:Human

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 11.5 kDa. Due to glycosylation, the protein migrates to 25-30 kDa based on Bis-Tris PAGE result.

Target Name:ALK-1/Activin RL1SynonymsACVRLK1; ORW2; ALK1; ALK-1; EC 2.7.11; HHT; HHT2; SKR3; TSR-I; ACVRL1

Target Information:Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in cardiovascular disease and cancer. Structural analyses reveal a tripartite recognition mechanism that defines BMP9 and BMP10 specificity for ALK1, and predict that crossveinless 2 is not an inhibitor of BMP9, which is confirmed by experimental evidence.

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)