Description:NebuSelect™ Recombinant Human GARP (G139N) &Latent TGF Beta 1 Complex, Avi-His-tag(Cat#NBL-242610) is expressed in HEK293 with His tag and Avi tag at the C-Terminus.It contains His20-Leu628 (GARP(G139N)) & Leu30-Ser390 (Latent TGF Beta 1).

Species:Human

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 70.3 kDa (GARP(G139N))&41.4 kDa (Latent TGF Beta 1). Due to glycosylation, the protein migrates to 75-80 kDa (GARP(G139N))&15 kDa&42-48 kDa (Latent TGF Beta 1) based on Bis-Tris PAGE result.

Target Name:GARP(G139N)&Latent TGF Beta 1 ComplexSynonymsLRRC32; GARP; LAP; TGF-beta-1; LRRC32&TGF-beta 1; LRRC32&TGFB1

Target Information:GARP&Latent TGF Beta is a complex found on surface of many types of cells. In Tregs, GARP is involved in TCR-mediated activation of Latent TGF-β and thus promoting secretion and activation of TGF-β. Integrin αvβ8 on the surface of immune cells and other cells recognizes RGD in LAP, resulting in the release of mature TGF-β from the TGF-β&GARP complex.

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)