Description:NebuSelect™ Recombinant Human IGFBP-3R, hFc-tag(Cat#NBL-242523) is expressed in HEK293 with hFc tag at the C-Terminus.It contains Ser39-Arg204.

Species:Human

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 44.5 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.

Target Name:IGFBP-3RSynonymsIGFBP-3R; GFBP3R; LOC124446; TMEM219

Target Information:Insulin-like growth factor-binding protein-3 (IGFBP-3) is a multifunctional protein known for modulating mitogenic and metabolic actions of IGFs as well as exerting a variety of biological actions not involving IGF. IGFBP-3 inhibits airway inflammation and hyper-responsiveness via an IGF-independent mechanism that involves activation of IGFBP-3R signaling and cross-talk with NF-κB signaling. The IGFBP-3/IGFBP-3R system therefore plays a pivotal role in the pathogenesis of asthma and can serve as a newly identified potential therapeutic target for this debilitating disease.

Amino Acid Sequence: Ser39-Arg204

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)