Description:NebuSelect™ Recombinant Human IGF1R/CD221, Avi-His-tag(Cat#NBL-242522) is expressed in HEK293 with His tag and Avi tag at the C-Terminus; It contains Glu31-Asn932.

Species:Human

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 105.8 kDa (alpha subunit) and 23 kDa (beta subunit). Due to glycosylation, the protein migrates to 110-120 kDa (alpha subunit) and 52-55 kDa (beta subunit) based on Bis-Tris PAGE result.

Target Name:IGF1R/CD221SynonymsCD221; IGF1R; IGF-1R; IGF-I R; IGF-I receptor; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216

Target Information:The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)