Description:NebuSelect™ Recombinant Mouse Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer, His-tag(Cat#NBL-242416) is expressed in HEK293 with His tag at the C-Terminus.It contains Leu32-Arg988 (ITGA2B) acidic tail and Glu26-Asp717 (ITGB3) basic tail.

Species:Mouse

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 109.80 kDa (ITGA2B) and 80.80 kDa (ITGB3). Due to glycosylation, the protein migrates to 90-113 kDa based on Bis-Tris PAGE result.

Target Name:Integrin alpha 2B beta 3 (ITGA2B&ITGB3) HeterodimerSynonymsITGA2B&ITGB3; ITGA2B; ITGB3

Target Information:Glanzmann thrombasthenia (GT) is characterized by mucocutaneous bleeding due to platelets that fail to aggregate in response to physiologic stimuli. GT, a rare inherited disease, is caused by quantitative or qualitative deficiencies of αIIbβ3, an integrin receptor for adhesive proteins. Coded by the ITGA2B and ITGB3 genes, αIIbβ3 mediates platelet-to-platelet attachment, aggregation and clot retraction.

Amino Acid Sequence: Leu32-Arg988(ITGA2B) acidic tail & Glu26-Asp717(ITGB3) basic tail

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)