Description:NebuSelect™ Recombinant Mouse KLRG1, hFc-tag(Cat#NBL-242394) is expressed in HEK293 with hFc tag at the N-Terminus.It contains Gln57-Tyr188.

Species:Mouse

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 42.3 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Bis-Tris PAGE result.

Target Name:KLRG1SynonymsKLRG1; CLEC15A; MAFA; MAFAL; 2F1; CLEC15AMAFA-LIKE; MGC13600

Target Information:Immune homeostasis requires the tight, tissue-specific control of the different CD4 Foxp3 regulatory T (Treg) cell populations. The cadherin-binding inhibitory receptor killer cell lectin-like receptor G1 (KLRG1) is expressed by a subpopulation of Treg cells with GATA3 effector phenotype.Lack of KLRG1 on Treg cells conferred on them a competitive advantage in the gut, but not in lymphoid organs. Hence, although absence of KLRG1 is not enough to increase intestinal Treg cells in KLRG1 knockout mice, KLRG1 ligation reduces T-cell receptor signals and the competitive fitness of individual Treg cells in the intestine.

Amino Acid Sequence: Gln57-Tyr188

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)