Description:NebuSelect™ Recombinant Human LAIR1/CD305, hFc-tag(Cat#NBL-242387) is expressed in HEK293 with hFc tag at the C-Terminus.It contains Gln22-His163.

Species:Human

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 42.4 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.

Target Name:LAIR1/CD305SynonymsCD305; HLAIR1; LAIR1; LAIR-1

Target Information:LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)