Description:NebuSelect™ Recombinant Human MMP-8, His-tag(Cat#NBL-242296) is expressed in HEK293 with His tag at the C-Terminus. The protein needs to be activated by APMA to have hydrolytic activity.It contains Phe21-Gly467.

Species:Human

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 52.2 kDa. Due to glycosylation, the protein migrates to 65-70 kDa based on Bis-Tris PAGE result.

Target Name:MMP-8SynonymsMMP-8; PMNL-CL; CLG1; MMP8; Collagenase 2; PMNL-CL; HNC

Target Information:Alteration of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) expression has been studied for various cardiac diseases, including dilated cardiomyopathy (DCM), with the significance of surrogate markers of extracellular matrix (ECM) remodeling. MMP-8 was identified only in myocardiocytes, while MMP-9 and TIMP-2 were present in both myocardiocytes and stroma, but with different intensity. The increasing intensity of MMP-8 and TIMP-2 immunoreactions was significantly associated with low HCS.

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)