Description:NebuSelect™ Recombinant Human Notch 1, Avi-His-tag(Cat#NBL-242234) is expressed in HEK293 with His tag and Avi tag at the C-Terminus.It contains Ala19-Gln526.

Species:Human

Expression System:HEK293

Molecular Weight: The protein has a predicted MW of 56.5 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.

Target Name:Notch 1SynonymsNotch-1; TAN1; NOTCH1; 9930111A19Rik; lin-12; Mis6; N1

Target Information:Human Notch-1 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes.Notch-1 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.

Amino Acid Sequence: Ala19-Gln526

Purity:＞95%

Endotoxin:＜1EU/ug(LAL Method)